关于举行新加坡国立大学Jie,关于举行第一届软物质科学与技术学术交流会的通知

关于举行新加坡国立大学Jie,关于举行第一届软物质科学与技术学术交流会的通知

告知标题:Label-free single-molecule quantification of chemicallyinduced
dimerization报 告 人:Jie
Yan教师,新加坡共和国国立学院报告时间:3月1日(周一)九:00告诉地方:大学城校区B陆-207报告厅招待广大师生踊跃加入!生物科学与工程高校201捌年3月十24日内容摘要:Chemically
induced dimerization (CID) refers to utilizing small molecules to induce
dimerization of two protein domains. CID has been applied to study
numerous biological processes through precise spatiotemporal control of
protein-protein interactions. In addition, CID also has important
pharmaceutical applications. CID involves complex multi-step
interactions. Precise quantification of each step of the interactions is
critical to our understanding of the stability and kinetics of the final
ternary complex formed through CID. CID is often associated with very
slow off rates in some of the steps, making them technically challenging
to be quantified using most of the current biochemistry assays. In
addition, in many applications the final ternary complex is subject to
various mechanical constraints, which cannot be quantified using current
technologies. Here, I will present a highly efficient label-free
single-molecule assay that can quantify each step of CID reactions and
demonstrate the application of the technology by quantifying each key
interaction involved in rapamycin induced heterodimerization of FRB and
FKBP protein domains. I will also show that the high mechanical
stability of the FRB-rapamycin-FKBP ternary complex can be utilized to
control mechanosensing of cells.报告人简单介绍:Yan Jie is currently a
professor at Department of Physics at National University of Singapore.
He is also a principal investigator at NUS Mechanobiology Institute and
NUS Centre for BioImaging Sciences. In 20一5, Yan Jie was awarded
American Physical Society (APS) Fellowship. And in 201陆, he received the
Singapore National Research Foundation (N奥迪Q伍F) Investigatorship as well as
the Human Frontier Science Programs Research 格兰特s. He has published 99research papers on journals including Nature, Nature Communication,
PNAS, and eLife. He received one PhD in experimental biophysics form
University of Illinois, Chicago (200伍), and one PhD from Institute of
西奥retical Physics, Chinese Academy of Sciences (一99八).附属类小部件:无

广阔师生:

Abstract

为越来越推进笔者校与国内外软物质研商世界学者的学术交换,华南软物质科学与才具高档切磋院于201七年1月十七日(星期五)实行第2届软物质科学与技能学术交换会,会议分别诚邀美利坚合众国梅奥管理学大旨(Mayo
Clinic)迈克尔 J.
Yaszemski教授、东华大学杨曙光教授、北大张文彬切磋员、华工生命调查斟酌院杜金志研究员以及软物质商讨院青年教授作学术报告。

The rapid development of new anticancer

  1. 报告时间:20壹七年1月七日(周二)晚上九:00开端

drugs that are safe and effective is a common goal shared by basic
scientists,

2.
告诉地方:华工发光质地与器件国家根本实验室(北区科学和技术园壹号楼)W50贰会议室

clinicians and patients. The current review discusses one such agent,
namely

  1. 告知剧情:

niclosamide, which has been used in the clinic for the treatment of
intestinal

告诉标题壹:Biofabrication and Commercialization of Tissue
Engineering/Regenerative Medicine Products

parasite infections. Recent studies repeat-edly identified niclosamide
as a

报告人:Dr. Michael J. Yaszemski,美国Mayo Clinic

potential anticancer agent by various high-throughput screening
cam-paigns.

告诉标题2:Genetically Encoded Click Chemistry: New Tools for
Protein-based Materials

Niclosamide not only inhibits the Wnt/b-catenin, mTORC1, STAT3, NF-jB
and Notch

报告人:张文彬切磋员,北大

signaling pathways, but also targets mitochondria in cancer cells to
induce

报告标题叁:Hydrogen-Bonded Polymer Complex Fiber: Elastic, Conductive
and Self-healing

cell cycle arrest, growth inhibition and apoptosis. A number of studies
have

报告人:杨曙光教师,东华东军事和政院学

established the anticancer activities of niclosamide in both in vitro
and in

告诉标题四:Tumor-acidity activated nanomedicine for cancer therapy

vivo models. Moreover, the inhibitory effects of niclosamide on cancer
stem

报告人:杜金志教授,华工生命科研院

cells provide further evidence for its consideration as a promising drug
for

报告标题伍:X-ray and Neutron Scattering Studies of Giant Molecular
Clusters

cancer therapy. This article reviews various aspects of niclosamide as
they

报告人:殷盼超讨论员,华南软物质科学与技术高端切磋院

relate to its efficacy against cancer and associatedmolecular mechanisms.

告知标题6:Microparticle Templating as a Route to Nanoscale Polymer
Vesicles with Controlled Size Distribution

Introduction

报告人:李文物博物格教师,华南软物质科学与技艺高档商讨院

Niclosamide (trade name Niclocide), ateniacide in the anthel-mintic
family which is especially effective againstcestodes, has
beenapprovedforuseinhumansfornearly50 years(Fig.1)[1,2].
Niclosamideinhibits oxidative phosphorylation and stimu-lates adenosine
triphosphataseactivity in the mitochondria of ces-todes (eg. tapeworm),
killing the scolexand proximal segments of the tapeworm both in vitro
and in vivo [2].Niclosamide is well tolerated in humans. The treatment
of Taenia saginata
(beeftape-worm),Diphyllobothriumlatum(fishtapeworm)andDipylidiumcaninum
(dog tapeworm) in adult is 2 g as a single oral dose. For the
treatmentof Hymenolepis nana (dwarf tapeworm), the same oral dose is
used for 7 days[2].

资料科学与工程高校

Drug development, from the initial lead

华南软物质科学与才具高端探究院

discovery to thefinal medication, is an expensive, lengthy

2017年12月4日

and incremental process [3]. Finding new uses for old or failed drugs
is much

附:

faster and more economical than inventing a new drug from scratch, as
existing drugs

  1. Biofabrication and Commercialization of Tissue
    Engineering/Regenerative Medicine Product(Dr.Michael J. Yaszemski)

have known pharmacokinetics and safety profiles and have often

报告人简单介绍:Dr. 迈克尔 J. Yaszemski is the Krehbiel Family Endowed
Professor of Orthopedic Surgery and Biomedical Engineering at the Mayo
Clinic and director of its Polymeric Biomaterials and Tissue Engineering
Laboratory. He served as president of the Mayo Clinic medical staff from
20一3-201肆, and had served for 拾 years as the Chair of the Spine Surgery
Division of the Department of Orthopedic Surgery at Mayo Clinic
Rochester prior to entering the presidential line. He received both
Bachelors and Masters degrees in Chemical Engineering from Lehigh
University in 197柒 and 一九七七, an M.D. from Georgetown University in 1玖八三and a Ph.D. in Chemical Engineering from the Massachusetts Institute of
Technology in 1995. He organized and then served as the first Chair of
the Musculoskeletal Tissue Engineering study section at NIH, and served
as a member of the Advisory Council of the NIH National Institute of
Biomedical Imaging and Bioengineering from 2010-201四. He is currently a
member of the NIH Advisory Council of the National Institute of
Arthritis, Musculoskeletal, and Skin Diseases. He served as Chair of the
FDA Center for Devices and Radiologic Health Advisory Committee, and is
currently a member of the FDA Science Board. He is an emeritus member of
the Lehigh University Board of Trustees. His clinical practice
encompasses spine surgery and musculoskeletal oncology. His research
interests are in the synthesis and characterization of novel degradable
polymers for use in bone regeneration, cartilage regeneration, nervous
tissue regeneration, and controlled delivery of chemotherapeutic agents
to musculoskeletal tumors.

been approved for human use, therefore any newly identified use(s) can be
rapidly evaluated in clinical trials [4]. In the

  1. Genetically Encoded Click Chemistry: New Tools for Protein-based
    Materials(张文彬切磋员)

last 5 years niclosamide has been identified as a potentialanticancer
agent by various high-throughput screening campaigns. This
arti-clereviews the current studies regarding various aspects of
niclo-samide as theyrelate to its potential new use in cancer therapy.

内容摘要:Genetically encoded chemistry provides versatile control over
the process of chemical reactions and the resulting materials. The
spontaneous formation of an isopeptide bond between a peptide tag and
its protein partner is a genetically encoded, cell-compatible, highly
specific and efficient chemistry for protein/peptide conjugation, as
demonstrated in the chemically reactive pair of SpyTag/SpyCatcher. In
this talk, I will give a brief overview of our work in the development
of genetically encoded protein chemistry tools (especially those
possessing features of click chemistry) and the use of such tools to
create bioactive materials. Through protein engineering, we have
successfully developed a chemical toolbox of genetically encoded
chemical reactions. The possibility to encode chemical information into
protein sequences has allowed the direct cellular synthesis of cyclic
proteins, tadpole proteins, star proteins, and other branched
topologies. The reaction between proteins bearing multiple reactive
groups also lead to all-protein-based bioactive hydrogels, whose
macroscopic properties are fully genetically encodable. By combining
this chemistry with protein folding, protein catenanes and other complex
protein topologies can be prepared.四 In general, catenation was found to
increase proteins stability toward proteolytic digestion and thermal
denaturation. It has thus opened new ways to engineer proteins
properties, both in 小米 and in vitro.

Niclosamide – a multiple pathway inhibitorfor anti-cancer efficacy

报告人简介:Wen-Bin Zhang is currently an Assistant Professor at the
Department of Polymer Science and Engineering, College of Chemistry and
Molecular Engineering of Peking University. He received his B.S. in
Organic Chemistry from Peking University in 200四 and his Ph.D. in
Polymer Science from the University of Akron in 20拾. He continued at
the University of Akron for his postdoctoral research under the
supervision of Prof. 史蒂芬 Cheng for one year, before he moved to
Caltech for a second postdoctoral training with Prof. David Tirrell in
Protein Engineering and Biomaterials. His current research interests
include the rational development of materials that bridges synthetic
systems and biological systems for energy and health-related
applications. In particular, he is interested in developing genetically
encoded protein click chemistry and the use of such tools for protein
topology engineering and protein-based bioactive materials.

Recently, several studies reported theinhibitory effects of niclo-samide
on multiple intracellular signalingpathways. The signaling molecules in
these pathways are either over-expressed,constitu-tively activeor
mutated inmany cancercells, andthus render niclosamide as a
potentialanticancer agent. The effects of niclosa-mide on these pathways
are describedbelow.

  1. Hydrogen-Bonded Polymer Complex Fiber: Elastic, Conductive and
    Self-healing(杨曙光教授)

The Wnt/b-catenin pathway

内容摘要:Polymer complex is a highly miscible aggregation of different
polymers. Polymer complexes can be divided into different types
according to the molecular interaction, such as polyelectrolyte complex
and hydrogen-bonded complex. We develop special methods to prepare
hydrogen-bonded polymer complex into fibers. First, a spinnable fluid is
obtained by restricting hydrogen bonds, and then it is extruded through
a spinneret into a coagulation bath where hydrogen bonds are built to
make fiber formation. Utilizing hydrogen-bonded polymer complex, we
produce elastic, self-healing and conductive fibers, which show
potential applications in flexible electronics.

The Wnt/b-catenin signaling pathway

报告人简介:Prof. Shuguang Yang received his BS of Chemistry (二零零四) at
Wuhan University and PhD of Polymer Science (贰零零伍) at Institute of
Chemistry, Chinese Academy of Sciences (CAS). He was research assistant
(2007-2010) in Department of Polymer Science and Engineering, Peking
University, and Postdoc Research Associate (贰零零九-2010) in Department of
Polymer Science, University of Akron. He has been professor of Material
Science and Engineering since 20十, and associated director of Center
for Advanced Low-dimension Materials, Donghua University since 201陆. His
academic interest is on structure and dynamics of low-dimension
materials and his research is polymer complexes, coacervates, films,
membrane and fibers.

regulates cancer progres-sion, including tumor initiation, tumor growth,
cell

附件:无

senescence, cell death, differentiation and metastasis [5–7]. In the
absence of

Wnt, b-catenin is sequestered in a complex that consists of the
adenomatous

polyposis coli (APC) tumor suppressor, axin, glycogen synthase kinase-3b

(GSK3b), and casein kinase 1 (CK1). This complex formation induces the

phosphorylation of b-catenin by CK1 and GSK3b, which results in the

ubiquitination and subsequent degradation of b-catenin by the 26S
proteasome.

Conversely, when Wnt proteins form a ternary complex with the cell
surface

recep-tors, low-density lipoprotein receptor-related protein5/6 (LRP5/6)
and

Frizzled (Fzd), signaling from Wnt receptors proceeds through the
proteins

dishevelled (Dvl) and axin, leading to the inhibition of GSK3b and the

stabilization of cytosolic b-catenin. The b-catenin then translocates
into the

nucleus where it interacts with T-cell factor/lymphoid enhancing factor
(TCF/LEF)

to induce the expres-sion of specific target genes [5–7] (Fig. 2A).

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